http://www.biology4kids.com/files/cell2_mitosis.html
http://www.life.umd.edu/cbmg/faculty/wolniak/wolniakmitosis.html
http://www.life.umd.edu/cbmg/faculty/wolniak/wolniakmitosis.html
MITOSIS - WHEN CELLS SPLIT APART
Eventually cells need to duplicate. There are two main methods of replication, mitosis and meiosis. This tutorial will talk about mitosis.
The big idea to remember is that mitosis is the simple duplication of a cell and all of its parts. It duplicates its DNA and the two new cells (daughter cells) have the same pieces and genetic code. Two identical copies come from one original. Start with one; get two that are the same. You get the idea.
Beyond the idea that two identical cells are created, there are certain steps in the process. There are five (5) basic phases in the life-cycle of a cell. You should remember the term PMATI (pronounced PeeMahtEee). PMATI is the acronym for the phases of a cell's existence. It breaks down to.
Events during Mitosis
Interphase: Cells may appear inactive during this stage, but they are quite the opposite. This is the longest period of the complete cell cycle during which DNA replicates, the centrioles divide, and proteins are actively produced. For a complete description of the events during Interphase, read about the Cell Cycle.
Prophase: During this first mitotic stage, the nucleolus fades and chromatin condenses into chromosomes. Each replicated chromosome comprises two chromatids, both with the same genetic information. Microtubules of the cytoskeleton, responsible for cell shape, motility and attachment to other cells during interphase, disassemble. And the building blocks of these microtubules are used to grow the mitotic spindle from the region of the centrosomes.
Prometaphase: In this stage the nuclear envelope breaks down so there is no longer a recognizable nucleus. Some mitotic spindle fibers elongate from the centrosomes and attach to kinetochores, protein bundles at the centromere region on the chromosomes where sister chromatids are joined. Other spindle fibers elongate but instead of attaching to chromosomes, overlap each other at the cell center.
Metaphase: Tension applied by the spindle fibers aligns all chromosomes in one plane at the center of the cell.
Anaphase: Spindle fibers shorten, the kinetochores separate, and the chromatids are pulled apart and begin moving to the cell poles.
Telophase: The daughter chromosomes arrive at the poles and the spindle fibers that have pulled them apart disappear.
Cytokinesis: The spindle fibers not attached to chromosomes begin breaking down until only that portion of overlap is left. It is in this region that a contractile ring cleaves the cell into two daughter cells. Microtubules then reorganize into a new cytoskeleton for the return to interphase.
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